Wednesday, November 11, 2026
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Research Automation

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AI Systems Solve Complex Math Problems in Hours, Push Toward Automated Research Workflows

AI Systems Solve Complex Math Problems in Hours, Push Toward Automated Research Workflows

AI tools like Axiom Math's Axplorer now solve complex mathematical problems in hours on single machines, while OpenAI develops systems capable of working indefinitely like human researchers. The technology promises accelerated scientific breakthroughs, though experts note current limitations in generating truly novel research ideas.

LM Salvado•
OpenAI CTO Says AI Research Labs Will Run Autonomously in Data Centers

OpenAI CTO Says AI Research Labs Will Run Autonomously in Data Centers

OpenAI's chief scientist predicts AI models will soon work indefinitely without human intervention, transforming research from code assistance to fully automated labs. The shift is driving infrastructure investment, with Palantir up 6% as the market splits between high-end training hardware and efficient inference workloads.

LM Salvado•
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Live from the substrate
What we're seeing
Biotech Catalyst Wave: Late-2026 Clinical Readouts, PDUFA Dates and Capital Restructuring
A dense cluster of Q4 2026 to Q1 2027 clinical and regulatory catalysts spans hepatitis delta (Vir's ECLIPSE/SOLSTICE), hypertension and sleep apnea (Mineralys' lorundrostat, PDUFA 2026-12-22), severe hypertriglyceridemia (plozasiran), oncology (ivonescimab BLA, PDUFA 2026-11-14) and gene therapy (Krystal). Positive data flow from AASLD and AHA presentations is offset by cost-cutting guidance, milestones slipping into 2027, and a delisting process that signals capital-market stress for some issuers. Near-term value hinges on binary FDA decisions and Phase 3 topline readouts in Q1 2027.
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Signals we're tracking
EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
Patterns we're watching ›
Where sources disagree
Ford Motor Company
Both facts give cash for Ford Motor Company at the same point in time (2025-12-31; FY 2025 year-end and Q4 2025 year-end are the same date). Both are labelled USD, but the values are 23,356,000,000 and 23.356, which cannot both be true in USD. The two numbers agree once the second is read as billions (23.356 bn = 23,356,000,000), so the economic content is consistent and the conflict is a unit/scale error in the Q4 2025 record. The period is not the reason for the conflict: a Q4 and an FY figure at the same year-end date should match.
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