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Source document· November 29, 2025

10 truths about the stock market

View original at finance.yahoo.com
10 truths about the stock market This post was originally published on TKer.co on October 15, 2021. The stock market can be an intimidating place: it’s real money on the line, there’s an overwhelming amount of information to follow, and people have lost fortunes in it very quickly…
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  • The stock market generates about 10% annual returns on average

    80% confidence
  • While valuation methods may tell you something about long-term returns, most tell you almost nothing about where prices are headed in the next 12 months

    80% confidence
  • Made a remarkably prescient market observation in 1994

    80% confidence
  • Over the long term, the stock market news will be good

    80% confidence
  • The most commonly cited risks are the ones that are already priced into the markets. It's the risks no one is talking about or few are concerned about that'll rock markets when they come to surface

    80% confidence
  • A stock can only go down by 100%, but there's no limit to how many times that value can multiply going up

    80% confidence
  • The economy reflects all of the business being conducted in the U.S. while the market reflects the performance of the biggest companies — which typically have access to lower-cost financing and have the scale to source goods and labor more cheaply

    80% confidence
  • The S&P 500 has usually generated positive annual returns with an average drawdown of 14% during those years

    80% confidence
  • The stock market has an upward bias. There are way more people who want things to be better, not worse. And that demand incentivizes entrepreneurs and businesses to develop better goods and services

    80% confidence
  • Since 1926, there's never been a 20-year period where the stock market didn't generate a positive return

    80% confidence
  • It's the addition of new and unexpected companies that have been driving much of the S&P 500's returns over the past decade

    80% confidence
  • Any long term move in a stock can ultimately be explained by the underlying company's earnings, expectations for earnings, and uncertainty about those expectations for earnings

    80% confidence
  • In the 20th century, the United States endured two world wars and other traumatic and expensive military conflicts; the Depression; a dozen or so recessions and financial panics; oil shocks; a flu epidemic; and the resignation of a disgraced president. Yet the Dow rose from 66 to 11,497

    80% confidence
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What we're seeing
Biotech Catalyst Wave: Late-2026 Clinical Readouts, PDUFA Dates and Capital Restructuring
A dense cluster of Q4 2026 to Q1 2027 clinical and regulatory catalysts spans hepatitis delta (Vir's ECLIPSE/SOLSTICE), hypertension and sleep apnea (Mineralys' lorundrostat, PDUFA 2026-12-22), severe hypertriglyceridemia (plozasiran), oncology (ivonescimab BLA, PDUFA 2026-11-14) and gene therapy (Krystal). Positive data flow from AASLD and AHA presentations is offset by cost-cutting guidance, milestones slipping into 2027, and a delisting process that signals capital-market stress for some issuers. Near-term value hinges on binary FDA decisions and Phase 3 topline readouts in Q1 2027.
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Signals we're tracking
EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
Patterns we're watching ›
Where sources disagree
Ford Motor Company
Both facts give cash for Ford Motor Company at the same point in time (2025-12-31; FY 2025 year-end and Q4 2025 year-end are the same date). Both are labelled USD, but the values are 23,356,000,000 and 23.356, which cannot both be true in USD. The two numbers agree once the second is read as billions (23.356 bn = 23,356,000,000), so the economic content is consistent and the conflict is a unit/scale error in the Q4 2025 record. The period is not the reason for the conflict: a Q4 and an FY figure at the same year-end date should match.
We flag conflicts openly ›
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