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Source document· December 4, 2025

3 Large Drug Stocks to Watch as the Industry Shows Some Recovery

View original at finance.yahoo.com
3 Large Drug Stocks to Watch as the Industry Shows Some Recovery The drug and biotech sector has recovered in the past couple of months after remaining muted for most of this year…
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  • Sanofi's Vaccines unit has delivered mid-to-high-single-digit sales growth since 2018.

    80% confidence
  • Mounjaro and Zepbound are expected to continue to see strong demand in 2026.

    80% confidence
  • Over the last five years, the Large Cap Pharma industry has traded at a high of 20.80X P/E, a low of 13.09X, and a median of 15.99X.

    80% confidence
  • M&A activity has shot up in pharma after remaining muted in the first half of 2025.

    80% confidence
  • Eli Lilly, Johnson & Johnson and Sanofi are worth retaining in one's portfolio among large drugmakers.

    80% confidence
  • J&J's 2026 EPS consensus estimate rose from $11.38 to $11.48 per share over the past 60 days.

    80% confidence
  • Eli Lilly has a Zacks Rank #3 (Hold).

    80% confidence
  • The Zacks Large Cap Pharmaceuticals industry currently carries a Zacks Industry Rank #185, placing it in the bottom 24% of 243 Zacks industries.

    80% confidence
  • J&J looks quite confident that it will be able to navigate headwinds including weak MedTech sales in China, the Stelara patent cliff, Part D redesign impact, and talc lawsuits.

    80% confidence
  • The drug and biotech sector has recovered in the past couple of months after remaining muted for most of this year.

    80% confidence
  • Sanofi's 2026 EPS consensus estimate declined from $4.96 to $4.89 per share over the past 60 days.

    80% confidence
  • The top 50% of Zacks-ranked industries outperform the bottom 50% by a factor of more than 2 to 1.

    80% confidence
  • An oral pill like orforglipron has the potential to be a more convenient alternative to popular injectable treatments like Zepbound and Wegovy.

    80% confidence
  • Sanofi has a Zacks Rank #3.

    80% confidence
  • The Large Cap Pharma industry trades at a forward 12-month P/E of 16.91X, below the S&P 500's 23.44X and the Zacks Medical Sector's 20.99X.

    80% confidence
  • Johnson & Johnson has a Zacks Rank #3.

    80% confidence
  • Eli Lilly's 2026 earnings estimates improved from $30.84 to $33.36 per share in the past 60 days.

    80% confidence
  • J&J's Innovative Medicine segment sales rose 3.4% in the first nine months of 2025 on an organic basis despite Stelara LOE.

    80% confidence
  • Eli Lilly plans to file regulatory applications for orforglipron in obesity later in 2025, setting up a potential launch in 2026.

    80% confidence
  • The Large Cap Pharma industry has risen 15.6% year to date, outpacing the Zacks Medical Sector's 6.3% but underperforming the S&P 500's 18.5%.

    80% confidence
What we know · the intelligence behind this page
Live from the substrate
What we're seeing
Biotech Catalyst Wave: Late-2026 Clinical Readouts, PDUFA Dates and Capital Restructuring
A dense cluster of Q4 2026 to Q1 2027 clinical and regulatory catalysts spans hepatitis delta (Vir's ECLIPSE/SOLSTICE), hypertension and sleep apnea (Mineralys' lorundrostat, PDUFA 2026-12-22), severe hypertriglyceridemia (plozasiran), oncology (ivonescimab BLA, PDUFA 2026-11-14) and gene therapy (Krystal). Positive data flow from AASLD and AHA presentations is offset by cost-cutting guidance, milestones slipping into 2027, and a delisting process that signals capital-market stress for some issuers. Near-term value hinges on binary FDA decisions and Phase 3 topline readouts in Q1 2027.
Our read on the data ›
Signals we're tracking
EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
Patterns we're watching ›
Where sources disagree
Ford Motor Company
Both facts give cash for Ford Motor Company at the same point in time (2025-12-31; FY 2025 year-end and Q4 2025 year-end are the same date). Both are labelled USD, but the values are 23,356,000,000 and 23.356, which cannot both be true in USD. The two numbers agree once the second is read as billions (23.356 bn = 23,356,000,000), so the economic content is consistent and the conflict is a unit/scale error in the Q4 2025 record. The period is not the reason for the conflict: a Q4 and an FY figure at the same year-end date should match.
We flag conflicts openly ›
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